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Generic "Dilacor Xr" produces its antihypertensive effect primarily by relaxation of vascular smooth muscle with a resultant decrease in peripheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normotensives.
Generic "Dilacor Xr" has also been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal work loads.

Active Ingredients: Diltiazem hydrochloride
Inactive Ingredients: Mannitol, ethyl cellulose, hypromellose, hydrogenated castor oil, ferric oxides, silicon dioxide, magnesium stearate, gelatin, D&C Yellow No. 10, FD&C Red No. 40, D&C Red No. 28, titanium dioxide.

Generic "Dilacor Xr" is approved for treating various conditions, including:

• High blood pressure (hypertension)
• Certain irregular heart rhythms (arrhythmias), including atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia (PSVT)
• Chest pain (angina).

Studies have shown a slight increase in the rate of absorption of Generic "Dilacor Xr" when ingested with a high-fat breakfast; therefore, administration in the morning on an empty stomach is recommended.

Patients should be cautioned that the Generic "Dilacor Xr" capsules should not be opened, chewed or crushed, and should be swallowed whole.


Hypertension: Dosages must be adjusted to each patient's needs, starting with 180 mg or 240 mg once daily. Based on the antihypertensive effect, the dose may be adjusted as needed. Individual patients, particularly ?60 years of age, may respond to a lower dose of 120 mg. The usual dosage range studied in clinical trials was 180 mg to 480 mg once daily.
Current clinical experience with the 540 mg dose is limited; the dose may be increased to 540 mg with little or no increased risk of adverse reactions. Doses should not exceed 540 mg once daily.
While a dose of Generic "Dilacor Xr" given once daily may produce an antihypertensive effect similar to the same total daily dose given in divided doses, individual dose adjustment may be needed.

Angina: Dosages for the treatment of angina should be adjusted to each patient's needs, starting with a dose of 120 mg once daily, which may be titrated to doses of up to 480 mg once daily. When necessary, titration may be carried out over a 7 to 14 day period.

Generic "Dilacor Xr" should be stored at room temperature, away from moisture and heat. Generic "Dilacor Xr" capsules should be stored in an airtight container. Keep Generic "Dilacor Xr" and all medications out of the reach of children.

Generic "Dilacor Xr" is contraindicated in: patients with sick sinus syndrome except in the presence of a functioning ventricular pacemaker; patients with second or third degree AV block except in the presence of a functioning ventricular pacemaker; patients with hypotension (less than 90 mmHg systolic); patients who have demonstrated hypersensitivity to the drug; and patients with acute myocardial infarction and pulmonary congestion as documented by X-ray on admission.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Several literature reports have identified cases of Generic "Dilacor Xr" overdose, some with multiple drug ingestion, with both fatal and non-fatal outcomes. The reported events affected multiple body systems including the cardiovascular system (bradycardia, complete heart block, asystole, cardiac failure, arrhythmia, atrial fibrillation, palpitations, hypotension, ischemia, ECG changes), respiratory system (respiratory failure, hypoxia, dyspnea, pulmonary edema), central nervous system (loss of consciousness, convulsions, dizziness, confusion, agitation), gastrointestinal system (nausea, vomiting), skin and appendages (increased sweating), and other systems (hypotonia, iliac artery thrombosis, metabolic acidosis, increased blood glucose). The administration of ipecac to induce vomiting and activated charcoal to reduce drug absorption have been advocated as initial means of intervention.

As with any medicine, there are possible side effects with Generic "Dilacor Xr" However, not everyone who takes the medication will experience side effects. In fact, most people tolerate it well. When Generic "Dilacor Xr" side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.

The most common side effects of Generic "Dilacor Xr" include: Abdominal pain (stomach pain); Constipation; Drowsiness; Fatigue; Feelings of a rapidly or forcefully beating heart (palpitations); Flushing or hot flashes; Headaches; Nausea; A sore throat; Swelling or water retention in the hands, feet, or lower legs.

Due to the potential for additive effects, caution and careful titration are warranted in patients receiving Generic "Dilacor Xr" concomitantly with any agents known to affect cardiac contractility and/or conduction. Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Generic "Dilacor Xr". As with all drugs, care should be exercised when treating patients with multiple medications. Generic "Dilacor Xr" undergoes biotransformation by cytochrome P-450 mixed function oxidase. Co-administration of Generic "Dilacor Xr" with other agents which follow the same route of biotransformation may result in the competitive inhibition of metabolism. Especially in patients with renal and/or hepatic impairment, dosages of similarly metabolized drugs, particularly those of low therapeutic ratio such as cyclosporine, may require adjustment when starting or stopping concomitantly administer Generic "Dilacor Xr" to maintain optimum therapeutic blood levels. Concomitant administration of Generic "Dilacor Xr" with carbamazepine has been reported to result in elevated plasma levels of carbamazepine, resulting in toxicity in some cases.

Check your blood pressure and pulse rate regularly; this is important while you are taking Generic "Dilacor Xr". Ask your prescriber or health care professional what your blood pressure and pulse rate should be and when you should contact him.
You may feel dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how Generic "Dilacor Xr" affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks; they can make you more dizzy or increase flushing and rapid heartbeats.
If you are going to have surgery, tell your prescriber or health care professional that you are taking Generic "Dilacor Xr".
Do not suddenly stop taking Generic "Dilacor Xr". Ask your prescriber or health care professional how to gradually reduce the dose.