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Generic "Eldepryl" is a selective inhibitor of MAO-B; MAO-B metabolizes dopamine. Generic "Eldepryl" exhibits little therapeutic benefit when used independently, but enhances and prolongs the anti-Parkinson effects of levodopa. It acts on the nervous system to increase the levels of a chemical called dopamine. Low dopamine levels in the brain are responsible for many of the symptoms of Parkinson's disease, so this medication works by rebalancing the levels of dopamine. This medication may be taken alone or in combination with levodopa to treat the symptoms of Parkinson's disease.

Active Ingredients: Selegiline hydrochloride
Inactive Ingredients: citric acid, lactose, magnesium stearate, and microcrystalline cellulose.

Generic "Eldepryl" is prescribed along with levodopa/carbidopa for people with Parkinson's disease. It is used when levodopa/carbidopa no longer seems to be working well. Generic "Eldepryl" has no effect when taken by itself; it works only in combination with levodopa or levodopa/carbidopa. Parkinson's disease, which causes muscle rigidity and difficulty with walking and talking, involves the progressive degeneration of a particular type of nerve cell. Early on, levodopa or levodopa/carbidopa alone may alleviate the symptoms of the disease. In time, however, these medications work less well; their effectiveness seems to switch on and off at random, and the individual may begin to experience side effects such as involuntary movements and "freezing" in mid-motion.
Generic "Eldepryl" may be prescribed at this stage of the disease to help restore the effectiveness of levodopa or levodopa/carbidopa. When you begin to take Generic "Eldepryl", you may need a reduced dosage of the other medication.

The recommended regimen for the administration of Generic "Eldepryl" is 10 mg per day administered as divided doses of 5 mg each taken at breakfast and lunch. There is no evidence that additional benefit will be obtained from the administration of higher doses. Moreover, higher doses should ordinarily be avoided because of the increased risk of side effects. After two to three days of Generic "Eldepryl" treatment, an attempt may be made to reduce the dose of levodopa/carbidopa. A reduction of 10 to 30% was achieved with the typical participant in the domestic placebo controlled trials who was assigned to Generic "Eldepryl" treatment. Further reductions of levodopa/carbidopa may be possible during continued Generic "Eldepryl" therapy.

Store this medicine at room temperature away from moisture and heat.

Generic "Eldepryl" should not be taken by anyone who: is allergic to selegiline or any of the ingredients of the medication; has problems such as excessive tremor or involuntary movements of the muscles of the face; has severe psychosis or severe dementia; is taking the medication called meperidine (and possibly other narcotic pain relievers); has active peptic ulcers.

Take it as soon as you remember. If you do not remember until late afternoon or evening, skip the dose you missed and go back to your regular schedule. Never take 2 doses at once.

Symptoms of a Generic "Eldepryl" overdose may include severe headache, hallucinations, vision problems, sweating, cool or clammy skin, fast or uneven heart rate, feeling light-headed, fainting, or seizure (convulsions).

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Generic "Eldepryl" and call your doctor at once if you have any of these serious side effects:
sudden and severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure (convulsions), and sudden numbness or weakness (especially on one side of the body); feeling light-headed, fainting; hallucinations; feeling restless, agitated, or irritable;
twitching muscle movements; or painful or difficult urination.

Continue taking Generic "Eldepryl" and talk with your doctor if you have any of these less serious side effects: dizziness, weakness; sleep problems (insomnia); runny or stuffy nose; back pain; constipation; or mouth sores or ulcers, pain with swallowing.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Before taking Generic "Eldepryl" tell your doctor if you are using any of the following drugs: carbamazepine (Tegretol); diet pills or cold medicines that contain ephedrine, pseudoephedrine, or phenylephrine; nafcillin (Unipen); phenobarbital (Luminal, Solfoton); rifampin (Rifadin, Rifater, Rifamate, Rimactane); or antidepressants such as amitriptyline (Elavil), amoxapine (Ascendin), bupropion (Wellbutrin, Zyban), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), venlafaxine (Effexor), or trimipramine (Surmontil).

If you are using any of these drugs, you may not be able to take Generic "Eldepryl" or you may need dosage adjustments or special tests during treatment.
There are many other medicines that can cause serious medical problems if you take them together with Generic "Eldepryl". Do not take Generic "Eldepryl" before telling your doctor about all other prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Keep a list with you of all the medicines you use and show this list to any doctor, dentist, or other healthcare provider who treats you.

Monitor therapeutic effectiveness according to rationale for therapy and adverse reactions at beginning of therapy and periodically throughout therapy. Monitor blood pressure. Be alert to thoughts of suicide.