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Generic Imuran is classified as an immunosuppressant medication. Generic Imuran is used to suppress the immune system in patients who have had kidney transplants. Although its exact mechanism of action in rheumatoid arthritis is not known, its effect in suppressing the immune system appears to decrease the activity of this illness.

Active Ingredients: azathioprine
Inactive Ingredients: lactose, magnesium stearate, potato starch, povidone, and stearic acid.

Generic Imuran is an immunosuppressive agent used to prevent rejection after a kidney transplant. It may also be used to treat rheumatoid arthritis and other conditions as determined by your doctor.

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Take Generic Imuran with a full glass of water. Take Generic Imuran with food to lessen stomach upset.
If you need to have any type of surgery, tell the surgeon ahead of time that you are using Generic Imuran. You may need to stop using the medicine for a short time.
Generic Imuran can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your kidney function may also to need to be tested. Do not miss any scheduled visits to your doctor.
Store Generic Imuran at 59 to 77 degrees F, in a sealed, light-resistant, container, avoid moisture.

Generic Imuran should not be given to patients who have shown hypersensitivity to the drug. Generic Imuran should not be used for treating rheumatoid arthritis in pregnant women. Patients with rheumatoid arthritis previously treated with alkylating agents (cyclophosphamide, chlorambucil, melphalan, or others) may have a prohibitive risk of neoplasia if treated with Generic Imuran.

If you take this medicine once daily and you miss a dose, take the medicine as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled time to take the medication. Do not use extra medicine to make up the missed dose.
If you take this medicine more than once daily and you miss a dose, take the medicine as soon as you remember. If it is almost time for the next dose, take both doses together, then go back to your regular dosing schedule.

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an Generic Imuran overdose may include nausea, vomiting, stomach pain, diarrhea, bleeding, fever, chills, and other signs of infection.

The most common serious side effects of Generic Imuran involve the blood elements and gastrointestinal system. Generic Imuran can cause serious lowering of the white blood cell count, resulting in an increased risk of infections. This can reverse when the dose is reduced or temporarily discontinued. Generic Imuran can cause nausea, vomiting, and loss of appetite, which can resolve when the dose is reduced or divided through the day. Generic Imuran can also cause liver toxicity (in less than 1% of rheumatoid arthritis patients). All patients taking Generic Imuran require regular blood testing for blood counts and liver function tests for monitoring. Other side effects encountered less frequently include fatigue, hair loss, joint pains, and diarrhea.

Generic Imuran can cause an increase in cancer risk when used long-term. This particular risk increases in patients with a prior history of treatment with other powerful immunosuppressants, such as Cytoxan, Leukeran, and Alkeran. It also increases the risk of serious infections. Azathioprine can impair fertility by reducing sperm counts in males. Because Generic Imuran's toxicity increases when taken with the gout medication allopurinol (Zyloprim), its dose is reduced with simultaneous use. Severely low white blood counts can occur when taken with other drugs that can affect the bone marrow or with ACE-inhibitor class drugs used to treat elevated blood pressure, such as Accupril and Vasotec. The safety and effectiveness for use in children has not been established.

Patients being started on Generic Imuran should be informed of the necessity of periodic blood counts while they are receiving the drug and should be encouraged to report any unusual bleeding or bruising to their physician. They should be informed of the danger of infection while receiving Generic Imuran and asked to report signs and symptoms of infection to their physician.