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Generic Indocin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. It is similar to ibuprofen (Motrin) and naproxen (Naprosyn, Aleve). Generic Indocin works by reducing the production of prostaglandins. Prostaglandins are chemicals that the body uses to cause fever, pain and inflammation. Generic Indocin blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and thereby reduces the levels of prostaglandins. As a result, fever, pain and inflammation are reduced. Generic Indocin is available in a sustained (slow) release form (Indocin-SR).

Active Ingredients: indomethacin
Inactive Ingredients: colloidal silicon dioxide, FD&C Blue 1, FD&C Red 3, gelatin, lactose, lecithin, magnesium stearate, and titanium dioxide.

Take Generic Indocin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take Generic Indocin with food, milk, or an antacid to lessen stomach upset.
Do not break, crush, or chew the sustained-release formulations of Generic Indocin. Swallow them whole.
Store Generic Indocin at room temperature away from moisture and heat. The suppositories and suspension can be stored at room temperature or in the refrigerator.

You may not be able to take Generic Indocin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the following conditions:
• have an allergy to aspirin or any other NSAIDs,
• have an ulcer or bleeding in the stomach,
• drink more than three alcoholic beverages a day,
• have liver or kidney disease,
• have a coagulation (bleeding) disorder,
• have congestive heart failure,
• have fluid retention,
• have heart disease, or
• have high blood pressure.

Do not use Generic Indocin suppositories without first talking to your doctor if you have a history of inflammation of the rectum (proctitis) or if you have recently had rectal bleeding.

If you miss a dose of Generic Indocin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

If overdose is suspected, contact your local poison control center or emergency room immediately.
Symptoms may include confusion; decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe headache; severe nausea or stomach pain; slow or troubled breathing; unusual bleeding or bruising; vomit that looks like coffee grounds.

Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous.
If you experience any of the following serious side effects, stop taking Generic Indocin and seek medical attention or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); muscle cramps, numbness, or tingling; ulcers (open sores) in the mouth; rapid weight gain (fluid retention); seizures; decreased hearing or ringing in the ears; yellowing of the skin and eyes (jaundice); or abdominal cramping, indigestion, or heartburn.

Potential Generic Indocin drug interactions may occur involving medications such as warfarin, lithium, cyclosporine, and methotrexate. In addition, taking other nonsteroidal anti-inflammatory drugs with Generic Indocin can result can lead to potentially dangerous drug interactions. When certain medicines are taken together with Generic Indocin, drug interactions may increase the risk of developing serious health problems, such as major bleeding, stomach ulcers, and kidney damage.

Before taking Generic Indocin, tell your doctor if you are taking any of the following drugs:
• aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, others);
• another nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Motrin, Advil, others), ketoprofen (Orudis, Orudis KT), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn, Anaprox, others), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
• an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, indomethacin, or ketoprofen;
• an anticoagulant (blood thinner) such as warfarin (Coumadin);
• a steroid such as prednisone (Deltasone);
• insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others;
• probenecid (Benemid);
• lithium (Eskalith, Lithobid, others); or
• bismuth subsalicylate in drugs such as Pepto-Bismol.

Avoid alcohol or use it with moderation. If you drink more than three alcoholic beverages a day, Generic Indocin may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking Generic Indocin if you drink more than 3 alcoholic beverages a day.