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Generic Kytril is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist with little or no affinity for other serotonin receptors, including 5-HT1; 5-HT1A; 5-HT1B/C; 5-HT2; for alpha1-, alpha2-, or beta-adrenoreceptors; for dopamine-D2; or for histamine-H1; benzodiazepine; picrotoxin or opioid receptors.

Serotonin receptors of the 5-HT3 type are located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. During chemotherapy that induces vomiting, mucosal enterochromaffin cells release serotonin, which stimulates 5- HT3 receptors. This evokes vagal afferent discharge, inducing vomiting. Generic Kytril blocks serotonin stimulation and subsequent vomiting after emetogenic stimuli such as cisplatin.

Active Ingredients: granisetron hydrochloride
Inactive Ingredients: hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, and titanium dioxide.

Generic Kytril is used to prevent nausea and vomiting due to cancer drug treatment (chemotherapy) and radiation therapy. It works by blocking one of the body's chemicals (serotonin) that causes vomiting.

Take Generic Kytril tablets by mouth. Swallow the tablets with a drink of water. Generic Kytril is given within 60 minutes before chemotherapy. In some cases, a second dose is given about 12 hours after the first dose.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
Keep Generic Kytril out of the reach of children in a container that small children cannot open.
Store at room temperature between 15—30 degrees C (56—86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

Generic Kytril is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take Generic Kytril without first talking to your doctor if you are pregnant or if you are planning a pregnancy. It is not known whether Generic Kytril passes into breast milk. Do not take Generic Kytril without first talking to your doctor if you are breast-feeding a baby.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

Seek emergency medical attention if you think you have taken too much of Generic Kytril. The only known symptom of a Generic Kytril overdose is headache.

If you experience any of the following uncommon but serious side effects, stop taking Generic Kytril and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (swelling of the lips, tongue, or face, difficulty breathing, closing of the throat, or hives); irregular heartbeats; or muscle cramps or uncontrollable movements.
Other, less serious side effects may be more likely to occur. Continue to take Generic Kytril and talk to your doctor if you experience:
headache; fatigue, drowsiness, or dizziness; anxiety or agitation; or diarrhea or constipation.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Generic Kytril has not been reported to interact with other medicines. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with Generic Kytril.

Keep Generic Kytril and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Before taking Generic Kytril tell your prescriber if you have any of the following conditions:
• liver disease
• an unusual or allergic reaction to granisetron, ondansetron, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding