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This medicine contains the active ingredient primidone, which is an antiepileptic medicine. Its activity results partly from the action of primidone itself, and partly from its breakdown products, phenobarbital (phenobarbitone) and phenylethylmalonamide (PEMA). It is not fully understood how much of a role each of the three plays in the overall antiepileptic effect of this medicine.

The central nervous system is made up of many nerve cells that communicate with each other through electrical signals. These electrical signals bring about body movement by stimulating the nerves to the muscles. Normally there is relatively low level of electrical activity in the brain. In an epileptic fit excessive electrical activity builds up causing uncontrolled stimulation of the brain.

Generic "Myoril" has an inhibitory effect on brain cells and damps down electrical activity, preventing the excessive build up which causes the epileptic fit.

The precise mode of action is not fully understood but, in common with other anticonvulants, it appears to alter the electrical activity of the nerve cell membrane.

Active Ingredients: Primidone
Inactive Ingredients: Microcrystalline Cellulose, NF; Lactose, USP; Methylcellulose, USP; Sodium Starch Glycolate, NF; Talc, USP; Sodium Lauryl Sulfate, NF; Magnesium Stearate, NF;Water, USP, Purified, Yellow Iron Oxide, NF.

Generic "Myoril" is tablet: 250 mg, white, with "AYERST" imprinted on one side. Generic "Myoril" is prescribed, alone or in combination with other anti-epileptic medications, to control simple partial, complex partial and tonic-clonic seizures.

Take Generic "Myoril" with food or milk if stomach upset occurs. This medication must be taken as prescribed. Do not stop taking this drug suddenly without consulting your doctor as seizures may occur. It is important to take all doses on time to keep the level of medication in your blood constant. Take doses at evenly spaced intervals throughout the day and night.

For most adults and children 8 years of age and over, the usual maintenance dosage is 250 milligrams 3 or 4 times a day. If you need more, your doctor may increase the dose to five or six 250-milligram tablets. You should not take more than 500 milligrams 4 times a day (2000 milligrams or 2 grams).
In patients already receiving other anticonvulsants, the usual starting dose of Mysoline is 100 to 125 milligrams at bedtime; your doctor will gradually increase this dose to a maintenance level as the other drug is gradually decreased.

Do not store in the bathroom.
Do not freeze liquid forms.
Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from heat, moisture and sunlight.
Keep away from children.

Avoid activities which require mental alertness until you and your doctor agree that your current dosage does not make you drowsy. Regular blood level checks must be done every 6 months. Older patients with kidney problems must also be monitored periodically. If you are pregnant or breast feeding an infant, discuss with your doctor whether you should continue to take Generic "Mysoline".

If you miss a dose, take as soon as remembered unless it is within 1 hour of your next dose. If so, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Any medication taken in excess can have serious consequences. Symptoms of an overdosage are: confusion; continuous, uncontrolled back-and-forth and/or rolling eye movements; double vision; shortness of breath or troubled breathing.
If you suspect a Generic "Mysoline" overdose, seek medical attention immediately.

Generic "Mysoline" may cause: drowsiness, sleepiness, stomach upset, loss of appetite, clumsiness, fatigue, seizures, double vision, fever, sore throat, skin rash.
If any of these effects persist or worsen, notify your doctor. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

If Generic "Mysoline" is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Generic "Mysoline" with the following:


depressants called MAO inhibitors, such as Parnate and Nardil;
blood-thinning drugs such as Coumadin;
doxycycline (Doryx, Vibramycin);
estrogen-containing oral contraceptives such as Ortho-Novum and Triphasil;
griseofulvin (Fulvicin-U/F, Grifulvin V);
steroid drugs such as Decadron.

Avoid alcoholic beverages while you are taking Generic "Mysoline".

Do not allow anyone else to take this medication.
Remember that you must not stop taking Generic "Mysoline" suddenly.
It can take several weeks for the full effectiveness of Generic "Mysoline" to be seen.
Since Generic "Mysoline" is generally given for long periods of time, your doctor will check your blood count every 6 months.