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Generic "Premarin" is an estrogen replacement drug. It belong to the class of medications known as estrogen replacement therapy. Estrogen is a female hormone that is produced by the ovaries. Once menopause is reached, the ovaries produce less estrogen and symptoms of menopause can occur.
Generic "Premarin" can help relieve symptoms of the menopause (hot flashes, night sweats, mood changes, and vaginal dryness and irritation), and also help to prevent osteoporosis (thin weak bones). Generic "Premarin" can also help improve female functions in women with hormonal imbalance or problems with their ovaries.

Active Ingredients: Sodium Estrone Sulfate and Sodium Equilin Sulfate
Inactive Ingredients: Calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.

Generic "Premarin" is used to reduce moderate to severe symptoms of menopause, including feelings of warmth in the face, neck, and chest, and the sudden intense episodes of heat and sweating known as "hot flashes."

This medication is also prescribed for teenagers who fail to mature at the usual rate, and to relieve the symptoms of certain types of cancer, including some forms of breast and prostate cancer.

Along with diet, calcium supplements, and exercise, Generic "Premarin" tablets are also prescribed to prevent postmenopausal osteoporosis, a condition in which the bones become brittle and easily broken.

Generic "Premarin" comes as a tablet to take orally. Take Generic "Premarin" exactly as directed by your doctor. The dose is prescribed individually to each patient. Do not chew or crush the tablet. Swallow it whole with full glass of water. It is preferable to take this medicine with food to avoid stomach upset.

Generic "Premarin" should be stored at room temperature (below 30 degrees C). Avoid light and moisture.

Generic "Premarin" is contraindicated if you: have ever had a bad reaction to it, or have undiagnosed abnormal vaginal bleeding; have ever had breast cancer, uterine cancer, or any other "estrogen-dependent" cancer; have had any circulation problem involving blood clots; have had a stroke or heart attack in the past year; have liver disease; are pregnant, trying to become pregnant or breast-feeding.
Other conditions may also be a contraindication for taking Generic "Premarin". Make sure that your doctor knows your medical history before taking this drug.

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and go back to your regular schedule. Never try to "catch up" by doubling the dose.

Symptoms of conjugated estrogen overdose are: nausea, vomiting, withdrawal bleeding If you suspect an overdose of Generic "Premarin", seek medical attention instantly.

Below you can find a list of most serious side effects that if occur need medical attention immediately:
• bulging eyes
• sore throat, fever, chills, cough, and other signs of infection
• pain, swelling, or tenderness in the stomach
• loss of appetite
• weakness
• yellowing of the skin or eyes
• joint pain
• movements that are difficult to control
• rash or blisters
• hives
• itching
• swelling of the eyes, face, tongue, throat, hands, arms, feet, ankles, or lower legs
• hoarseness
• difficulty breathing or swallowing

Generic "Premarin"may increase your risk of developing cancer of the ovaries or gallbladder disease that may need to be treated with surgery. Talk to your doctor about the risks of taking Generic "Premarin".

Generic "Premarin" may cause growth to slow or stop early in children who take large doses for a long time. It may also affect the timing and speed of sexual development in children. Your child's doctor will monitor him/her carefully during his/her treatment with estrogen. Talk to your child's doctor about the risks of giving this medication to your child.

Talk to your doctor if some other side effects happen and last for a long time.

Generic "Premarin" tablets increase the liver's capacity to produce factors that promote the clotting of blood. Because of this, patients receiving warfarin (Coumadin), a drug that thins the blood and prevents clotting by reducing clotting factors, have to be monitored for loss of the blood thinning effect if treatment with an estrogen is begun.

Below are listed several drugs that increase the elimination of estrogen by enhancing the liver's ability to eliminate estrogens:
• Rifampin (Rifadin),
• barbiturates,
• carbamazepine (Tegretol),
• griseofulvin (Grifulvin),
• phenytoin (Dilantin),
• St. John's wort,
• Primidone.

Use of any of these medications with Generic "Premarin" may result in a reduction of the beneficial effects of estrogens.

Conversely, drugs such as:
• erythromycin,
• ketoconazole (Nizoral),
• itraconazole (Sporanox),
• ritonavir (Norvir)

may reduce the elimination of estrogens by the liver as and lead to increased levels of estrogens in the blood. Grapefruit juice also may increase levels of estrogen by increasing the absorption of estrogens from the intestine. Increased levels of estrogens in the blood may result in more estrogen-related side effects.