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Generic Topamax is a sulfamate-substituted monosaccharide. The precise mechanisms by which Generic Topamax exerts its anticonvulsant and migraine prophylaxis effects are unknown; however, preclinical studies have revealed four properties that may contribute to Generic Topamax's efficacy for epilepsy and migraine prophylaxis. Electrophysiological and biochemical evidence suggests that Generic Topamax, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV.

Active Ingredients: topiramate
Inactive Ingredients: lactose monohydrate, pregelatinized starch, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, purified water, carnauba wax, hypromellose, titanium dioxide, polyethylene glycol, synthetic iron oxide (50, 100 and 200 mg tablets) and polysorbate 80.

Generic Topamax is used with other medications to treat certain types of seizures in patients with epilepsy or Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Generic Topamax is used to treat patients who continue to have seizures even when they take other anti-seizure medications. Generic Topamax is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

Use Generic Topamax as directed by your doctor. Check the label on the medicine for exact dosing instructions. Generic Topamax may be taken with or without food. Drink plenty of fluids while taking Generic Topamax to prevent kidney stones from forming. Swallow Generic Topamax whole. Do not crush, break, or chew before swallowing. Suddenly stopping Generic Topamax may cause seizures to occur more often. Stopping therapy should be gradual. Ask your health care provider any questions you may have about how to use Generic Topamax.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Tablets should be stored at room temperature and away from excess heat and moisture (not in the bathroom).

Anyone with an allergy to Generic Topamax or any ingredients should not take this medication.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. You may have seizures if you miss doses of Generic Topamax.

Seek emergency medical treatment. Symptoms of a Generic Topamax overdose are unknown but may include severe drowsiness, poor coordination, tremor, confusion, difficulty speaking, and nausea.

If you experience any of the following serious side effects, stop taking Generic Topamax and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); blurred vision, changes in vision, or pain in or around the eyes; worsening of seizures.

Other, less serious side effects may be more likely to occur. Continue to take Generic Topamax and talk to your doctor if you experience: dizziness, poor coordination, sluggishness, or drowsiness; irregular back-and-forth movements of the eyes; nausea, loss of appetite, or weight loss; tremor, numbness, or tingling; confusion, difficulty concentrating or decreased memory; speech or language difficulties; or changes in behavior, depression, nervousness, or agitation.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome

Before taking Generic Topamax, tell your doctor if you are taking any of the following medicines: another seizure medication such as valproic acid (Depakote, Depakene), carbamazepine (Tegretol, Carbatrol, Epitol), phenytoin (Dilantin), and others; a carbonic anhydrase inhibitor such as acetazolamide (Diamox), methazolamide (Neptazane), or dichlorphenamide (Daranide); or digoxin (Lanoxin, Lanoxicaps).

You may not be able to take Generic Topamax, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the drugs listed above. Generic Topamax may decrease the effectiveness of birth control pills. Talk to your doctor about other birth control options to prevent unintended pregnancy. Generic Topamax may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, pain relievers, sedative (sleep aids), anxiety medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if Generic Topamax is taken with any of these medications. Drugs other than those listed here may also interact with Generic Topamax. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.