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Generic Embarin is a structural isomer of hypoxanthine (a natually occurring purine in the body) and acts to inhibit xanthine oxidase. This enzyme is responsible for the successive oxidation of hypoxanthine and xanthine resulting in the production of uric acid, the end-product of human purine metabolism. In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine, which are converted to closely related purine ribotides adenosine and guanosine monophosphates. Increased levels of these ribotides causes feedback inhibition of amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Generic Embarin therefore decreases both uric acid formation and purine synthesis.

Active Ingredients: allopurinol
Inactive Ingredients: corn starch, FD&C Yellow No. 6 Lake, lactose, magnesium stearate, and povidone

Generic Embarin is used to treat patients with multiple recurrent gout attacks, erosive destructive gouty joint disease, hard lumps of uric acid deposits in tissues (called tophi), gouty kidney disease, or uric acid stones. Generic Embarin is also used to prevent elevation of blood uric acid in patients undergoing chemotherapy for the treatment of certain cancers.