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Generic "Motilium" is a type of medicine called a dopamine antagonist.
Generic "Motilium" works primarily by blocking dopamine receptors found in an area of the brain known as the chemoreceptor trigger zone (CTZ). The CTZ is activated by nerve messages from the stomach when an irritant is present. It is also activated directly by agents circulating in the blood, for example anti-cancer medicines. Once activated, it sends messages to another area of the brain, the vomiting centre, which in turn sends messages to the gut, causing the vomiting reflex. Blocking the dopamine receptors in the CTZ prevents nausea messages from being sent to the vomiting centre. This reduces the sensation of nausea and prevents vomiting. Generic Generic "Motilium" also blocks dopamine receptors found in the upper end of the digestive system. This results in tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed the passage of food through the stomach into the intestine, which physically helps to prevent vomiting. Both actions make Generic "Motilium" useful in treating nausea and vomiting due to many causes, including anti-cancer chemotherapy, emergency hormonal contraception and in migraine.

Generic "Motilium" is a drug that has, as a side effect, stimulating or increasing milk production, probably by increasing prolactin production by the pituitary gland. Prolactin is the hormone that stimulates the cells in the mother's breast to produce milk. Generic "Motilium" increases prolactin secretion indirectly, by interfering with the action of dopamine whose action is to decrease the secretion of prolactin by the pituitary gland.

Active Ingredients: Domperidone

Generic "Motilium" is generally used for disorders of the gastrointestinal tract (gut).
Generic "Motilium" works particularly well to increase milk production under the following circumstances:
It has frequently been noted that a mother who is pumping milk for a sick or premature baby in hospital has a decrease in the amount she pumps around 4 or 5 weeks after the baby is born. The reasons for this decrease are likely many, but Generic "Motilium" generally brings the amount of milk pumped back to where it was or even to higher levels.
When a mother has a decrease in milk supply, often associated with the use of birth control pills (avoid Estrogen containing birth control pills while breastfeeding), or on occasion, for no obvious reason when the baby is 3 or 4 months old, Generic "Motilium" will often bring the supply back to normal.