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Generic "Nitroglycerin" - an organic nitrate with vasodilator activity. Generic "Nitroglycerin" is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, Generic "Nitroglycerin" causes coronary artery dilatation, thereby improving myocardial blood distribution.

Active Ingredients: Dextrose, nitroglycerin
Inactive Ingredients: Polyester film, silicone and acrylic adhesive with a cross-linking agent.

Generic "Nitroglycerin" is used as a heart medication, mainly in the following cases:
• Prophylaxis and treatment of angina and left ventricular failure.
• Control of hypertension during cardiac surgery.
• Congestive cardiac failure unresponsive to usual therapy.

The principal action of Generic "Nitroglycerin" is vasodilation—widening of the blood vessels.

Generic "Nitroglycerin" will dilate veins more than arteries, decreasing cardiac preload and leading to the following therapeutic effects during episodes of angina pectoris:
• subsiding of chest pain
• decrease of blood pressure
• increase of heart rate
• orthostatic hypotension

These effects arise because Generic "Nitroglycerin" is converted to nitric oxide in the body (by a mechanism that is not completely understood), and nitric oxide is a natural vasodilator.