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Generic Zofran is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting that is due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.

Active Ingredients: ondansetron hydrochloride
Inactive Ingredients: lactose, microcrystalline cellulose, pregelatinized starch, hypromellose, magnesium stearate, titanium dioxide, triacetin, and iron oxide yellow.

Generic Zofran helps to relieve nausea and vomiting, especially when associated with the treatment of cancer (chemotherapy). Generic Zofran may also be used to prevent or treat nausea and vomiting that occurs after surgery, and occasionally is used to treat severe vomiting during pregnancy